Estriol

A milder form of estrogen commonly used to support vaginal, skin, and menopausal comfort.

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Targeted, practical comfort support that helps you address the symptoms that impact daily life and intimacy.

Clinical evidence suggests local estriol therapy can improve vaginal symptom scores by ~

50–70%

over 8–12 weeks, including dryness and discomfort measures.

Why Choose Estriol?

Estriol supports estrogen receptors in local tissue, improving hydration and elasticity in areas affected by low estrogen, which helps reduce dryness, irritation, and discomfort

Estriol product

Because it is commonly used in localized formulations, many programs aim for symptom relief with lower systemic exposure compared to broader estrogen replacement

The best results come from consistent use over several weeks, with dosing tailored to symptom severity and medical history

Experience the science of Estriol

Supports vaginal and urinary comfort by improving tissue hydration and elasticity. Helps reduce dryness and irritation.

Supports comfortable intimacy by promoting healthier mucosal tissue and natural lubrication.

Helps reduce recurrent discomfort related to genitourinary syndrome of menopause with consistent use.

Supports local tissue health with minimal systemic absorption when used as directed.

Improves overall quality of life by addressing symptoms that are often overlooked.

How does Estriol support comfort?

Clinically Supervised Treatment

Consistency is key for meaningful symptom relief.

Estriol helps restore estrogen signaling in local tissue, improving hydration and elasticity so dryness and irritation decrease over time.

What would better comfort and confidence change for you?

Comparison Factors Estriol Lubricants & Moisturizers No Treatment
Safety Prescription estrogen with monitoring. Generally safe. N/A.
Administration Local topical. Topical. N/A.
Cost Moderate. Low. None.
Efficacy Strong for localized symptoms. Temporary relief. Symptoms persist.
Convenience Simple routine. As needed. N/A.
Regulation & Quality Prescription. OTC. N/A.
Long-Term Support Local tissue support. Symptom management only. None.

Supporting Research

A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections

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The therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy: results from a pivotal phase III study

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Oestriol in the prophylactic treatment of recurrent urinary tract infections in postmenopausal women

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A Phase II Prospective, Randomized, Double-Blind, Placebo-Controlled and Multicenter Clinical Trial to Assess the Safety of 0.005% Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women with Early Stage Breast Cancer in Treatment with Aromatase Inhibitor in the Adjuvant Setting

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Frequently Asked Questions