Super easy intake and quick follow up. My order arrived on time.
Estriol Cream | Hormone Replacement
In Stock
Compounded in U.S.A
FSA & HSA Eligible
Estriol estrogen topical cream for hormone replacement care.
Price range: $1.50 through $109.00
Product Details
Form:
Cream
Strength %:
3%
Strength (mg/g):
3 mg/g
Description
Estriol is an estrogen hormone available in topical cream form. Topical formulations are prescribed within hormone replacement related medical care under licensed medical supervision following clinical evaluation.
Why Explore
Explore Estriol cream if you and your provider are considering a milder estrogen option delivered topically as part of hormone replacement therapy.
Benefits
- May help support your estrogen balance
- Topical cream allows localized daily application
- Easy to integrate into your routine
- Often selected when gentle topical support is preferred
- Supports consistent use over time
- May contribute to comfort and quality of life
Specifications
Active Ingredient
Estriol
Inactive Ingredients
Purified Water, Emulsifying Wax, Glycerin, Propylene Glycol, Stearic Acid, Cetyl Alcohol, Isopropyl Myristate, Triethanolamine, Methylparaben, Propylparaben
Prescriber Directions
Administer as prescribed by a licensed healthcare provider.
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Fast shipping and consistent quality. I feel confident ordering here.
Clear communication at every step. No surprises and no stress.
I appreciated the reminders and the simple dosing guidance.
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Lab tested medications for quality & potency
Our medication is delivered from a state licensed pharmacy in our network, right to your door when you need it.
- Third party quality control testing
- Dispensed by state-licensed pharmacies
- Fast, discreet delivery
Ingredient information
Clinical evidence suggests local estriol therapy can improve vaginal symptom scores by ~
50–70%
over 8–12 weeks, including dryness and discomfort measures.
Why Choose Estriol?
Estriol supports estrogen receptors in local tissue, improving hydration and elasticity in areas affected by low estrogen, which helps reduce dryness, irritation, and discomfort
Because it is commonly used in localized formulations, many programs aim for symptom relief with lower systemic exposure compared to broader estrogen replacement
The best results come from consistent use over several weeks, with dosing tailored to symptom severity and medical history
Experience the science of Estriol
Supports vaginal and urinary comfort by improving tissue hydration and elasticity. Helps reduce dryness and irritation.
Supports comfortable intimacy by promoting healthier mucosal tissue and natural lubrication.
Helps reduce recurrent discomfort related to genitourinary syndrome of menopause with consistent use.
Supports local tissue health with minimal systemic absorption when used as directed.
Improves overall quality of life by addressing symptoms that are often overlooked.
How does Estriol support comfort?
Clinically Supervised Treatment
Consistency is key for meaningful symptom relief.
Estriol helps restore estrogen signaling in local tissue, improving hydration and elasticity so dryness and irritation decrease over time.
What would better comfort and confidence change for you?
| Comparison Factors | Estriol | Lubricants & Moisturizers | No Treatment |
|---|---|---|---|
| Safety | Prescription estrogen with monitoring. | Generally safe. | N/A. |
| Administration | Local topical. | Topical. | N/A. |
| Cost | Moderate. | Low. | None. |
| Efficacy | Strong for localized symptoms. | Temporary relief. | Symptoms persist. |
| Convenience | Simple routine. | As needed. | N/A. |
| Regulation & Quality | Prescription. | OTC. | N/A. |
| Long-Term Support | Local tissue support. | Symptom management only. | None. |
Supporting Research
A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections
Read StudyThe therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy: results from a pivotal phase III study
Read StudyOestriol in the prophylactic treatment of recurrent urinary tract infections in postmenopausal women
Read StudyA Phase II Prospective, Randomized, Double-Blind, Placebo-Controlled and Multicenter Clinical Trial to Assess the Safety of 0.005% Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women with Early Stage Breast Cancer in Treatment with Aromatase Inhibitor in the Adjuvant Setting
Read Study
How it Works
Step 1
Meet with provider
Fill out a quick online form and connect with a licensed medical provider. They'll review your goals and determine whether treatment is appropriate for you.
Step 2
Home delivery with ease
If approved, your medication is custom compounded and shipped directly to your home, fast, discreet, and secure.
Step 3
Ongoing care and support
You're not doing this alone. Pharmacy Time includes ongoing guidance, provider check-ins, and support to help you stay consistent and on track.
Frequently Asked Questions
Is Estriol Safe?
Estriol can be safe when prescribed appropriately, especially for localized use, but estrogen safety still depends on medical history. People with a history of estrogen-sensitive cancers, unexplained vaginal bleeding, clotting disorders, or severe liver disease need clinician guidance. Providers consider whether a uterus is present and whether additional hormone protection is needed. "Local" does not always mean "risk-free," so proper screening matters.
What Are The Side Effects Of Estriol?
Common side effects include local irritation, discharge, or spotting, especially early in treatment. Systemic effects such as breast tenderness or headaches are less common but can occur depending on absorption and dosing. Rare but serious concerns include clotting risk in susceptible individuals and evaluation-needed bleeding. Seek medical evaluation for persistent bleeding, severe pelvic pain, or breast changes.
What Is Estriol?
Estriol is a weaker estrogen that is often used for localized menopausal symptoms such as vaginal dryness, irritation, or urinary discomfort. It is typically delivered via vaginal creams, tablets, or suppositories to target tissues directly. Because it is usually used locally, systemic exposure may be lower than with some other estrogen therapies.
What is the difference between oral supplements and cream?
Oral supplements are processed through digestion, while topical creams are applied to the skin for localized or controlled absorption.
Who should not use this medication?
This medication may not be appropriate for individuals who are pregnant, breastfeeding, or who have hormone sensitive conditions. A licensed provider will determine eligibility.
Can this medication interact with other medications?
Yes. Estriol may interact with other medications or therapies. Your provider will review your full medication list.
Is this medication FDA approved?
This compounded medication is not FDA approved to diagnose, treat, cure, or prevent disease.
What is included in Pharmacy Time's treatment plans?
All plans include a telehealth consultation, a personalized prescription if approved, medication prepared by a licensed compounding pharmacy, shipping, and access to a care team.
Who are the providers I'll be working with?
Our clinical providers are Wasef Health, PC c/o Michael Wasef MD. They can be contacted at contact@wasef-health.com. Wasef Health PC has its office located at 5260 78th Ave N, PO Box 1697, Pinellas Park, FL, 33780.
What pharmacies do you work with?
F&F Pharmacies Inc dba Jungle Jim's Pharmacy is located at 5484 Dixie Highway Fairfield, OH 45014. They can be contacted at (877) 858-3784. They are able to dispense medications and maintain a license in 44 US states. Unfortunately, they cannot dispense sterile compounds and do not have a license in the following US states: CALIFORNIA, NEVADA, NEW JERSEY, NORTH CAROLINA, TEXAS, MASSACHUSETTS, MISSISSIPPI, NEW HAMPSHIRE, WEST VIRGINIA, and DELAWARE.
Are in-person visits required?
No. Care is provided entirely through telehealth.
How do I get started?
You begin by completing the online intake form. A licensed provider will guide you through next steps if appropriate.