Super easy intake and quick follow up. My order arrived on time.
Estradiol Cream | Hormone Replacement
In Stock
Compounded in U.S.A
FSA & HSA Eligible
Estradiol estrogen topical cream for hormone replacement care.
$109.00
Product Details
Form:
Cream
Strength %:
2%
Strength (mg/g):
2 mg/g
Description
Estradiol is an estrogen hormone available in topical cream form. Topical formulations are prescribed within hormone replacement related medical care under licensed medical supervision following clinical evaluation.
Why Explore
Explore Estradiol cream if estrogen support is part of your hormone replacement plan and a topical formulation is being considered for hormone related changes.
Benefits
- May help support your estrogen balance
- Topical cream allows localized daily application
- Easy to use as part of your morning or evening routine
- Often chosen when you prefer non oral options
- Supports consistent use over time
- May contribute to comfort and quality of life
Specifications
Active Ingredient
Estradiol
Inactive Ingredients
Purified Water, Emulsifying Wax, Glycerin, Propylene Glycol, Stearic Acid, Cetyl Alcohol, Isopropyl Myristate, Triethanolamine, Methylparaben, Propylparaben
Prescriber Directions
Administer as prescribed by a licensed healthcare provider.
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Lab tested medications for quality & potency
Our medication is delivered from a state licensed pharmacy in our network, right to your door when you need it.
- Third party quality control testing
- Dispensed by state-licensed pharmacies
- Fast, discreet delivery
Ingredient information
Clinical evidence shows estradiol therapy can reduce hot flash frequency by ~
50–80%
in many patients, with meaningful improvements often seen within 4–12 weeks.
Why Choose Estradiol?
Estradiol replaces or supplements estrogen to address symptoms caused by declining levels, helping reduce vasomotor symptoms like hot flashes and night sweats
It also supports tissue health in the genitourinary system, improving comfort and quality of life when dryness or irritation is present
Because estrogen therapy should be individualized, the best outcomes come from symptom-guided dosing, appropriate route selection, and ongoing monitoring for safety
Experience the science of Estradiol
Relieves common menopausal symptoms by supporting healthy estrogen levels. Helps reduce hot flashes and night sweats.
Supports vaginal and urinary comfort by improving tissue hydration and elasticity.
Helps stabilize mood and sleep disruption associated with hormonal changes.
Supports bone density maintenance by addressing estrogen related turnover.
Supports overall hormonal balance when tailored to individual needs and risks.
How does Estradiol help
relieve menopausal symptoms?
Clinically Supervised Treatment
With the right plan, symptom relief can be both measurable and sustainable.
Estradiol restores estrogen signaling that declines during menopause, which can reduce hot flashes, improve sleep disruption, and support tissue comfort.
What would fewer disruptions and better comfort change for you?
| Comparison Factors | Estradiol | OTC Menopause Supplements | No Treatment |
|---|---|---|---|
| Safety | Prescription estrogen with monitoring. | Variable. | N/A. |
| Administration | Topical, oral, or other routes. | Oral. | N/A. |
| Cost | Moderate. | Low to moderate. | None. |
| Efficacy | Strong symptom relief. | Variable. | Symptoms persist. |
| Convenience | Varies by route. | Easy. | N/A. |
| Regulation & Quality | Prescription. | Unregulated. | N/A. |
| Long-Term Support | Hormone balance and symptom control. | Limited. | None. |
Supporting Research
Initial 17beta estradiol dose for treating vasomotor symptoms
Read StudyEffects of ultralow dose transdermal estradiol on bone mineral density a randomized clinical trial
Read StudyEffects of hormone therapy on cognition and mood in recently postmenopausal women the KEEPS Cog trial
Read StudyTreatment of skin aging with topical estrogens
Read Study
How it Works
Step 1
Meet with provider
Fill out a quick online form and connect with a licensed medical provider. They'll review your goals and determine whether treatment is appropriate for you.
Step 2
Home delivery with ease
If approved, your medication is custom compounded and shipped directly to your home, fast, discreet, and secure.
Step 3
Ongoing care and support
You're not doing this alone. Pharmacy Time includes ongoing guidance, provider check-ins, and support to help you stay consistent and on track.
Frequently Asked Questions
What Are The Side Effects Of Estradiol?
Common side effects include breast tenderness, nausea, headaches, bloating, mood changes, and spotting or breakthrough bleeding. Potential serious risks (depending on individual profile, dose, and route) include blood clots, stroke, gallbladder disease, and certain cancer risks when used inappropriately or without indicated progesterone in those with a uterus. Seek urgent care for chest pain, shortness of breath, sudden severe headache, one-sided weakness, or leg swelling/pain.
What Is Estradiol?
Estradiol is a primary form of estrogen used in hormone therapy. It is prescribed for menopausal symptoms (hot flashes, night sweats), vaginal symptoms, and sometimes for bone health support in appropriate candidates. It comes in different forms such as oral tablets, patches, gels, and vaginal preparations. The form and dose matter because they affect risk profile and systemic exposure.
Is Estradiol Safe?
Estradiol can be safe and effective when prescribed after a careful evaluation of personal risk factors. It is not appropriate for everyone, especially those with a history of blood clots, stroke, certain cancers (like estrogen-sensitive breast cancer), or uncontrolled liver disease. In people with a uterus, estrogen is often paired with progesterone to reduce the risk of endometrial overgrowth. Providers typically assess age, timing since menopause, personal/family clot history, migraines, smoking status, and cardiovascular risk.
What is the difference between oral supplements and cream?
Oral supplements pass through digestion, while topical cream is applied to the skin for localized or systemic absorption under medical supervision.
Who should not use this medication?
This medication may not be appropriate for individuals who are pregnant, breastfeeding, or who have certain hormone-sensitive or medical conditions.
Can this medication interact with other medications?
Yes. Estradiol may interact with other medications or supplements. Your provider will review safety considerations.
Is this medication FDA approved?
No. This medication is compounded by a state-licensed pharmacy and is not FDA approved to treat or prevent any disease.
What is included in Pharmacy Time's treatment plans?
Treatment plans include telehealth consultation, personalized prescription if approved, pharmacy preparation, shipping, and care access.
Who are the providers I'll be working with?
Our clinical providers are Wasef Health, PC c/o Michael Wasef MD. They can be contacted at contact@wasef-health.com. Wasef Health PC has its office located at 5260 78th Ave N, PO Box 1697, Pinellas Park, FL, 33780.
What pharmacies do you work with?
F&F Pharmacies Inc dba Jungle Jim's Pharmacy is located at 5484 Dixie Highway Fairfield, OH 45014. They can be contacted at (877) 858-3784. They are able to dispense medications and maintain a license in 44 US states. Unfortunately, they cannot dispense sterile compounds and do not have a license in the following US states: CALIFORNIA, NEVADA, NEW JERSEY, NORTH CAROLINA, TEXAS, MASSACHUSETTS, MISSISSIPPI, NEW HAMPSHIRE, WEST VIRGINIA, and DELAWARE.
Are in-person visits required?
No. All services are provided online through telehealth.
How do I get started?
You begin by completing an online questionnaire reviewed by a licensed provider.